The Longest-Running Evolution Experiment
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If you ran evolution all over again, would you get humans? How repeatable is ? This video is sponsored by @BountyBrand.

Special thanks to Prof. Richard Lenski and team for showing me around the lab - it is an honor to be able to witness and document such a historic science experiment.
Thanks to Dr Zachary Blount for the help with research and setting up the competition time-lapse, Dr Nkrumah Grant for microscope images of the long-term line cells @NkrumahGrant
Devin Lake, Kate Bellgowan, and Dr. Minako Izutsu for being part of this video. Long Live the LTEE!

LTEE website - myxo.css.msu.edu/ecoli/index.html
Intro footage courtesy of the Kishony Lab - kishony.technion.ac.il
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References:
Lenski, R. E., \u0026 Travisano, M. (1994). Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations. Proceedings of the National Academy of Sciences, 91(15), 6808-6814. - ve42.co/Lenski1994

Lenski, R. E., Rose, M. R., Simpson, S. C., \u0026 Tadler, S. C. (1991). Long-term experimental evolution in Escherichia coli. I. Adaptation and divergence during 2,000 generations. The American Naturalist, 138(6), 1315-1341. - ve42.co/Lenski1991

Good, B. H., McDonald, M. J., Barrick, J. E., Lenski, R. E., \u0026 Desai, M. M. (2017). The dynamics of molecular evolution over 60,000 generations. Nature, 551(7678), 45-50. - ve42.co/Good2017

Blount, Z. D., Borland, C. Z., \u0026 Lenski, R. E. (2008). Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proceedings of the National Academy of Sciences, 105(23), 7899-7906. - ve42.co/Blount2008

Blount, Z. D., Lenski, R. E., \u0026 Losos, J. B. (2018). Contingency and determinism in evolution: Replaying life’s tape. Science, 362(6415). - ve42.co/Blount2018

Wiser, M. J., Ribeck, N., \u0026 Lenski, R. E. (2013). Long-term dynamics of adaptation in asexual populations. Science, 342(6164), 1364-1367. - ve42.co/Wiser2013

N, Scharping. (2019). How a 30-Year Experiment Has Fundamentally Changed Our View of How Evolution Works. Discover - ve42.co/Scharping

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Special thanks to Patreon supporters: Mike Tung, Evgeny Skvortsov, Meekay, Ismail Öncü Usta, Paul Peijzel, Crated Comments, Anna, Mac Malkawi, Michael Schneider, Oleksii Leonov, Jim Osmun, Tyson McDowell, Ludovic Robillard, Jim buckmaster, fanime96, Juan Benet, Ruslan Khroma, Robert Blum, Richard Sundvall, Lee Redden, Vincent, Marinus Kuivenhoven, Alfred Wallace, Arjun Chakroborty, Joar Wandborg, Clayton Greenwell, Pindex, Michael Krugman, Cy 'kkm' K'Nelson, Sam Lutfi, Ron Neal

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Research and Writing by by Derek Muller, Petr Lebedev and Casey Rentz
Animation by Iván Tello
Filmed by Derek Muller, Emily Zhang and Raquel Nuno
Edited by Derek Muller
Music by Jonny Hyman and from Epidemic Sound epidemicsound.com
Additional video supplied by Getty Images
Thumbnail image courtesy of the Kishony Lab
Produced by Casey Rentz
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Kommentteja
  • gyamlj
    gyamlj

    This is a highly controlled environment. Compare the competitive advantage of the newest and oldest colonies in a natural world where innumerable other factors weigh in to survival. It may very well be that the older organisms are better able to survive. This is analogous to selective breeding that creates an animal with desired characteristics but is otherwise less capable of overall survival compared to its ancestors. I'm afraid this teaches me nothing.

  • Ashethorama
    Ashethorama

    Did anyone else notice the reference from the movie “The 13th Warrior” on the fridge? Timestamp 7:50 minute

  • Seven Ligthson
    Seven Ligthson

    YES! Nothing out is not in and everything out is in ;-)) 1.5 (oo.000) is human program given by life = love = what you are in need of, who (do you) are (you)? I took my ABO once more!

  • Christopher Inman
    Christopher Inman

    Queen Elizabeth I (of England) cooked a fruitcake for members of parliament to celebrate its opening. A bit was saved to be included in the next parliament's opening, etc. So now, when parliament begins its new season, the members are privileged to have a bit of cake cooked by Shakespeare's favorite monarch! [i have not fact-checked this because i don't want to find out if it is not true]

  • maruftim
    maruftim

    Mad scientist fell into bacteria gacha hell...

  • AJ T
    AJ T

    Is he referring to Confirmation Bias or is it something else?

  • ZedCactus
    ZedCactus

    This episode was great! Really interesting.

  • Lief Bamberg
    Lief Bamberg

    disappoinited that derek is now hawking that idea that greater bacterial spread is somehow dirtier, and that you should use disposible environment wrecking paper over washable cloths.

  • WowZers
    WowZers

    Imagine being the chad bacteria to first eat the citrate

  • Rodrigo Segura
    Rodrigo Segura

    42, ¿coincidence? I think not

  • Frenchnostalgique
    Frenchnostalgique

    Prof Richard Lenski has the same accent as Rich Evans and it's throwing me off.

  • Azurium
    Azurium

    Me seeing 1% selection first hand: "So that's what the aliens are doing to our universe and what the Great Filter could be."

    • Azurium
      Azurium

      Context: imagine that at 7:30 he's talking about intergalactic species expanding across the universe.

  • Christian412 America
    Christian412 America

    The educated dumbasses still call it evolution. After 70000+ generations the bacteria is still producing bacteria. The bacteria has not produced anything but bacteria. Why is it so hard to get un biased conclusions? The only thing that has been observed is ADAPTATION not evolution.

    • Crispr CAS9
      Crispr CAS9

      "The educated dumbasses still call it evolution" Evolution is the change in allele frequencies in a population over successive generations, which this definitely is. "The bacteria has not produced anything but bacteria" If they produced something other than bacteria, it would disprove evolution. You understand that, right?

  • SuperSonic Boom
    SuperSonic Boom

    Nah, if the flask breaks we become the solution to the experiment.

  • Michael Kurek
    Michael Kurek

    It’s called mutation or adaptation. NOT EVOLUTION! The bacteria will always remain bacteria, just more resistant.

    • Crispr CAS9
      Crispr CAS9

      Evolution is the change in allele frequencies in a population over successive generations, which this definitely is.

  • Guy Fox
    Guy Fox

    IT'S GOD! LOL

  • Samaila Abdullahi
    Samaila Abdullahi

    I am forever grateful to Dr IGUDIA on FIbill who cured me from herpes with his herbal medication, you are so real and trusted.

  • RD2564
    RD2564

    Beautiful video. Biosciences are a rich hunting ground for new videos.

  • David Blank
    David Blank

    So...when do they turn into monkeys??? Can monkeys evolve into bacteria???

    • Crispr CAS9
      Crispr CAS9

      "So...when do they turn into monkeys" Based on evolutionary science, never. If you think evolution suggests otherwise, you don't understand evolution.

  • DeadEndFrog
    DeadEndFrog

    well don't judge the Qu when they do this to us :^)

  • lalit pal
    lalit pal

    I see you evolving from young youtuber :D

  • wildstar2424242424
    wildstar2424242424

    A million bacterial monkeys typing on a million bacterial type-writers.... One of them finally wrote the opening to hamlet

  • Mike Tacos
    Mike Tacos

    13:48 A couple more generations and they’ll be growing eyes and noses.

  • Mike Tacos
    Mike Tacos

    Then someone breaks the glass.

  • Chris Koll
    Chris Koll

    I'll bet you I can make a dog "evolve" so that it will CRAVE something that canines would NEVER consume if left to their own tastes(sp?)...

    • mwuaha
      mwuaha

      what?

  • Truther
    Truther

    Are tests like this being done on viruses?

  • FuriousGeezer
    FuriousGeezer

    So what you are saying is, after 75,000 generations, it's just better bacteria, but in the same amount of generations we went from monkey to man? Why didn't it macro evolve?

    • FuriousGeezer
      FuriousGeezer

      @Crispr CAS9 fair enough! I am still seeing no evidence of macro evolution, but that timeline sure makes it look like more of a possibility. My timeline was clearly off

    • Crispr CAS9
      Crispr CAS9

      @FuriousGeezer "it's a long time from bacteria to monkey" Monkeys are not descended from bacteria. "We get what a billion or so years?" 3.5 billion from first life to complex life, another 100 million to get on land, another 150 million for mammals, another 100 million for primates, another 50 for humans. Approximately.

    • FuriousGeezer
      FuriousGeezer

      @Crispr CAS9 Both are human though, yes. I poorly worded it.

    • FuriousGeezer
      FuriousGeezer

      @Crispr CAS9 it's a long time from bacteria to monkey and again to man. Not sure there is time for that🤷🏼‍♂️. We get what a billion or so years?

    • Crispr CAS9
      Crispr CAS9

      In the same number of generations, our ancestors went from Homo erectus to Homo sapiens. Both of those are humans.

  • Neiley
    Neiley

    so how long til one of the containers crawls off? :P

  • sf
    sf

    using the same needle for different flask samples???!!

  • Bangs Cutter
    Bangs Cutter

    The human scale equivalent of this would be alien abduction encounters, where aliens continuously sample humans as they observe our evolution.

  • Brad Shymon
    Brad Shymon

    Shouldn't forget all the generations of students who evolved the professor's knowledge and status! 🧐

  • realitycheck2001
    realitycheck2001

    Wait. She wasn’t wearing gloves. Am I missing something?

  • Gary CLark
    Gary CLark

    Ok thats stretch of a comparison. The mutations of a one cell bacterium are quite different than the mutations that would have to occur for an ape like creature to transform into what man is today. I don't care how many million years you tack on to it.

    • Crispr CAS9
      Crispr CAS9

      ​@Gary CLark "Many species remain virtually unchanged for millions of years, then suddenly disappear to be replaced by a quite different, but related, form." Let's say that was completely true for every group. How would it be relevant to anything in my prior comments, specifically? Does it provide a metric for 'flourishing'? Does is it address the greater fitness of chimpanzees in their environment? The nature of scientific theories and laws? No to all. Nor does it present a mechanism for 'crafting' organisms. Does it support any of your later statements that do address some of these? No again. So why bring it up? Most groups don't fit that pattern, by the way. "Moreover, most major groups of animals appear abruptly in the fossil record" First, same initial commentary as above. Anyway: If you mean in the Cambrian, then that is partially true, although we are starting to find some organisms from the Ediacaran. That's still enough to show the evolution of all vertebrates, for instance. " fully formed" We never expect to find any 'half-formed' organisms, that's not how evolution works. "and with no fossils yet discovered that form a transition from their parent group." This isn't a problem for human evolution. The fossil record is fairly extensive. "This pattern is contrary to what would be expected from Darwinian evolution." Darwinian evolution only makes predictions on what should be found in the fossil record in the sense of predicting the chronological order of specimens that might be found, not what should be found in the actual rocks. For instance, if an initial radiation occurs rapidly in a small population, especially for small and soft bodied animals, it is unlikely that we would find many fossils at all. But if we DID find some, then they should occur in a particular pattern. Failure to find the Ediacaran soft-bodied ancestors of vertebrates, for instance, is neither consistent with nor contrary to evolution. Finding a rabbit mixed in with the Ediacaran would definitely be contrary to evolution. "Genetics has punched more holes in it lately." Genetics provided a stronger support for evolution than any single field has ever provided to any single theory in the history of science. "and not to rely on random chance mutations to explain" Mutation is a known process that can do what needs to be explained. That certainly doesn't mean it is impossible for some other process to be involved, but until it is presented, mutation will continue to be the best explanation currently available. "I am however enjoying this conversation." I've talked to a few people under this video, you've been the best so far.

    • Gary CLark
      Gary CLark

      @Crispr CAS9 my reasoning for specific placements of species is as follows: Many species remain virtually unchanged for millions of years, then suddenly disappear to be replaced by a quite different, but related, form. Moreover, most major groups of animals appear abruptly in the fossil record, fully formed, and with no fossils yet discovered that form a transition from their parent group. This pattern is contrary to what would be expected from Darwinian evolution. Your partially right about laws and theories. I don't think one is better than the other, theories are more complex and less quantifiable. Going into the whys and hows. scientific law predicts the results of certain initial conditions. I think that evolution is as well established in proof and data as it should be considering it's been around for about 150 years. Genetics has punched more holes in it lately. I think we need more information from all kinds of sources, and not to rely on random chance mutations to explain the propagation of species on the whole planet without stepwise fossil records. I am however enjoying this conversation. It's been helpful to me to continue to formulate my ideas about how things came to be, so thank you.

    • Crispr CAS9
      Crispr CAS9

      @Gary CLark "I would consider flurishing of species is a metric of evolution" And what do you mean by flourishing? Think about it this way: At the end of this, we need to plug something into an equation. What is the *number*? ""survival of the fittest" I would also consider a metric of evolution." Great. Fitness here means differential reproductive success, which can be mathematically modeled. Chimpanzees have massively greater fitness in their environment than humans. Humans have higher fitness in ours. Both are extremely fit in their own environments. " I am using opinion because all these Ideas are theory" Theory isn't opinion, it is the highest level of science backed by monumental amounts of evidence. "and that many organisms are crafted in such a way as to place the greatest amount of organisms in a space where all can thrive" And what is the known mechanism to accomplish that? "we are quite a long way off from a law of evolution" There are many laws in evolution. A law in science is just a mathematical correlation. Laws are lower than theory, since theories contain many laws.

    • Gary CLark
      Gary CLark

      @Crispr CAS9 I would consider flurishing of species is a metric of evolution. , "survival of the fittest" I would also consider a metric of evolution. if these aren't metrics of evolution like the ability of the bacteria to evole to overcome the antibiotics and contitue to propogate, then what are we even talking about. I am using opinion because all these Ideas are theory, we have fossil records of what we think might have happened, we have similar genetic and physical structures that would indicated a similar ancestor, but let say for example that the reason for similar structures is that it this structure is best suited for it's environment and that many organisms are crafted in such a way as to place the greatest amount of organisms in a space where all can thrive. your talking like there are 1 set of facts that guide all of evolution and if it doesn't fit into some arbitrarily defined catagory than it isn't true, I'm saying we are quite a long way off from a law of evolution if there ever can be one. The problem is we don't know what we don't know.

    • Crispr CAS9
      Crispr CAS9

      @Gary CLark "less than 1billion in 1900 now we have almost 7 billion." Yes, the population has increased substantially. If you think that means 'more evolution', you're mistaken. "Suited to their environment and creating their own environment are two different things." Yes, because only one of them is indicative of evolution. So the substantial increase in population in humans isn't indicative of anything. "We are responsible for the sheep growth" Okay... So what's the metric for success again? You haven't said. "We are at the top of the apex hierarchy, which means have to power to destroy every living creature on the planet including ourselves." Which is technological advancement, not evolution. So still no point... "I would call that evolutionary superiority." You would definitely be wrong, then. That one isn't a matter of opinion. If it isn't evolution-related, it can't be evolutionary superiority. "Man does kill and for most of recorded history killing has been deemed immoral." If killing itself was immoral, the word 'murder' wouldn't exist. In any event, that introduces the possibility that a subset of chimpanzees might be doing something the rest consider immoral. Which essentially confirms my point. So...

  • Chris M
    Chris M

    Still waiting. When did bacteria have gain in function/information and become a dog? Nowhere in the world does that occur. Besides all fossils having soft cell tissues in them is clear and abundant evidence evolution does not occur. There are not enough trillions and quadrillions of years for "mutations" required to have gained in function as soft cell tissues have how long a life? Your experiment does nothing but proves the existence of a "pre-programmed will to survive" or immunity as your body posses. Mankind did not evolve from apes or will they evolve into something other than humans. Transitional fossils? Where?

    • Crispr CAS9
      Crispr CAS9

      @Chris M "That is the events evolution proposes." No, it isn't.

    • Chris M
      Chris M

      @Crispr CAS9 That is the events evolution proposes.

    • Crispr CAS9
      Crispr CAS9

      "When did bacteria [...] become a dog?" If bacteria became dogs, that would disprove evolution. You understand that, right?

  • Vinícius M
    Vinícius M

    E.Colocaust :(

  • Chris Carriere
    Chris Carriere

    Isn't it possible to try and make bacteria evolve into eating stuff we treat as garbage ? Like idk all the "bad" gases etc. Could solve a lot of problems

  • Stephanie Hyatt
    Stephanie Hyatt

    I hate to mention this, but unless you are composting your paper towels, use re-usable microfiber cloths that you can throw in the washer. I use them occasionally, but rarely for cleaning.

  • Ismael Abufon
    Ismael Abufon

    12:31 ... I 100% read Gattaca haha

  • Ismael Abufon
    Ismael Abufon

    The lucky 1% gets to reproduce..... like the super rich haha

  • Peter Smoyer
    Peter Smoyer

    Space itself is the thing that is evolving. All the matter, energy and radiation that exists in the universe at one time fit into something the size of a soccer ball or perhaps a football stadium. It all came from space. It is all here to benefit space. Space would not be as expansive as it is without the matter and energy it created in less than one second.

  • Antisocial Atheist
    Antisocial Atheist

    I could sit down and talk with that guy for days lol. Very interesting and informative. If I could meet him I'd have to thank him for his work

  • Plum Amazing
    Plum Amazing

    The best example of this kind of research is a really old story by the author of 'Game of Thrones' George R.R Martin. It's one of his best. It's a short story called 'Sandkings'. There is the book on youtube. Also the outerlimits video also on youtube. Sorry I can't put up links you'll have to search youtube. Very scary one to read. I suspect you will like it. muhahaha

  • Falsimer
    Falsimer

    When the music kicked in I got a wave of nostalgia. I saw your source, but what it reminded me of was the Majora's Mask Milk Bar Theme. The most simultaneously upbeat and sorrowful music I can think of right now. Only the first 5 or so notes of your music matched the Theme, but it was enough to spark my memory.

  • Benjamin Márkus
    Benjamin Márkus

    that transfer process was suprisingly lax! :o i would’ve thought you’d want to do this under suction cabinet with purified atmosphere and such.

  • sokin jon
    sokin jon

    “33 years ago, even on weekends ever since ..” Bacteria are annoyingly hard workers.

  • mbbs2008
    mbbs2008

    Perhaps this is adaptability? Quiet possible that bacteria have different (higher) adaptability potential then higher animals?. The bacteria still remained "bacteria" at the end, even after 30 years relentless "experimentation", and did no really "evolve" into a new species? Am I missing something?

  • mike powers
    mike powers

    This is a great experiment in micro evolution and also acts as an experiment in macro evolution as well, if macro evolution were possible there would be signs after 70k generations but, that is not the case. No matter how resilient or mutated these samples are they are still E. coli bacteria and not E. coli/??? Or something completely different.

    • sokin jon
      sokin jon

      stove, etc. It's WAY too wasteful to use paper towels! SHAME on you, for promoting such wastefulness!!

  • jonnyjazzz
    jonnyjazzz

    So this is what Chase is doing these days. Decided he liked the red-head look, too.

  • Emmanuel N
    Emmanuel N

    Evolution really isn't true devolution or decay is much more realistic

  • Tom James
    Tom James

    Where are the damn gloves?

  • Máté Ócsai
    Máté Ócsai

    This video was amazing. I was hooked from the beginning.

  • Roberto Serrini • The Travelclast
    Roberto Serrini • The Travelclast

    bounty blew my mind

  • Ad Lakerveld
    Ad Lakerveld

    It seems dangerous to me learning bacteria to survive antibiotics

  • X17
    X17

    This is a perfect plot for a disaster movie

  • X17
    X17

    why 42 though?

  • betaneptune
    betaneptune

    This is the great experiment Richard Dawkins describes in his book _The Greatest Show on Earth: The Evidence for Evolution_!

  • Ezgi Umut
    Ezgi Umut

    As far as I understand the environment in this experiment is strictly controlled with constant and optimal temperature and nutritional content. There are no other species present. E.coli to grow faster in such an environment is most likely explained by the fact that these bacteria evolve to spend less energy and time to adapt to different temperatures, nutritional shortages (ex. storing carbohydrates), and competing with other species, allowing them to concentrate all metabolic activity on growth and reproduction. Thus, the "constant improvement" proposed by the researcher is questionable. This is probably not an improvement, it is only an action of increasing the activity of only one vital metabolic function (growth by using glucose) at the expense of others (adaptation to temperature, nutritional shortage, competition, etc.).

    • Crispr CAS9
      Crispr CAS9

      @Ezgi Umut "My comment is not a claim" Yes it is. You claimed that something was the most likely explanation, you must support this. You've also made a collection of claims in your new comment, and provided support for none of them. You're just making stuff up, no one cares.

    • Ezgi Umut
      Ezgi Umut

      @Crispr CAS9 My comment is not a claim, rather a necessary discussion before accepting that this experiment provides evidence to "continuous improvement" in a stable environment. I consider that it should be called continuous adaptation to the experiment's growth medium. The first generation E.coli of this experiment comes from the real world where it spent significant energy to preserve membrane potential to the changing electrolyte concentrations of its habitat, to adapt to temperature changes and nutritional content as well as producing multiple enzymes to produce energy from many non-glucose substrates. The hospitable and stable environment provided in this experiment is expected to result in selective atrophy of the aforementioned metabolic features of the bacterium that it gained to survive harsh living conditions; allowing more energy to be spent on growth and reproduction rather than metabolic defensive buffers, competition, etc. The researcher has to disprove this interpretation before concluding that continuous improvement takes place even in stable conditions. These bacteria are still adapting to this new friendly habitat (no fluctuations in sodium, phosphate, potassium, magnesium, citrate, ammonium concentrations, temperature, nutrition ) even if it has been going on for 30 years (which is not a long time) especially considering that it is markedly different from what the bacteria have evolved in millions of years. The atrophy of previously essential functions with environmental change has been described in many species even in vertebrates in Galapagos.

    • Crispr CAS9
      Crispr CAS9

      @Ezgi Umut " It is more likely that the outcome (growth rate) is better not because of progress, but rather from the atrophy of other metabolic functions that are necessary for life in the real world" This is your claim, present your evidence to support it.

    • Ezgi Umut
      Ezgi Umut

      @Crispr CAS9 the ability to grow without glucose (ex. metabolizing citrate) is a different discussion that takes place during the video. However, the main topic of interest that the researcher emphasizes at the conclusion is the constant improvement of the growth rate which concerns the bacteria incubated at the standard DM25 liquid medium (10% glucose). It is more likely that the outcome (growth rate) is better not because of progress, but rather from the atrophy of other metabolic functions that are necessary for life in the real world, that have become obsolete in this experiment method.

    • Crispr CAS9
      Crispr CAS9

      "it is only an action of increasing the activity of only one vital metabolic function (growth by using glucose)" The interesting finding is that are able to grow in the complete absence of glucose. Are you sure you watched the video?

  • hoiy vinosa
    hoiy vinosa

    “33 years ago, even on weekends ever since ..” Bacteria are annoyingly hard workers.

  • Blue Five
    Blue Five

    I'm put in mind of 'The Outer Limits' episode 'Wolf 359'.

  • Soapy's Thoughts
    Soapy's Thoughts

    This reminds me of Primer

  • Yout Funny
    Yout Funny

    Evolution is Adaptation Adaptability

    • hoiy vinosa
      hoiy vinosa

      i just love the hippie labcoat at 11.50 :-) ....sadly not gonna happen in my lab :-(

  • Mary Ann Bittle
    Mary Ann Bittle

    Paper towels? Um, NO. Dish cloths, hand towels, sponges, all can be - get this - *WASHED* to sanitize them. No need, at ALL, to waste trees in order to wipe down the counter, stove, etc. It's WAY too wasteful to use paper towels! _SHAME on you,_ for promoting such wastefulness!!

  • Robe005
    Robe005

    Damn, the ThermoFisher ad was awesome. Don't know what it was but the music and video were very satisfying:)

  • Fred Bach
    Fred Bach

    No we're not viewing evolution as it happens. You are describing 'minor evolution' which is an adaptation to environment. It's still the same bug. It hasn't turned into another kind of bacteria. And the corn is still corn. Major evolution would result in a different bacterium or a different plant. I wish you evolutionists would stop lying to us. Stop using the smoke screen of minor evolution to prove that major evolution is a fact.

    • Crispr CAS9
      Crispr CAS9

      ​@Fred Bach "That was a library addition using Crisper " I don't know which experiment you're talking about, but it isn't any of the ones featured in this video. "Let me know when it turns into something that is not an E-coli." 'E coli' is a species designation, and species designations are human labels for human abstractions of populations. A sub population of E coli is no longer E coli when humans decide it, and by the ecotype conception of species delimitation the Ara-3 strain is already a new species. "Does the citrate ability come via the Rogues' Gallery or from elsewhere in the genome?" The citrate ability comes from a novel mutation, as confirmed by genomic sequencing of the ancestral and descendant strains. " If the latter, what will happen if you took the citrate away for 75000 generations? Might it lose its ability to handle citrate? " Sounds like you just suggested it can't be evolution if *more* evolution happens afterwards. I hope that isn't what you intended, since that would be silly.

    • Fred Bach
      Fred Bach

      @Crispr CAS9 the bugs were given a Rogues gallery of what compounds to be immune to. For instance the square carbon ring in penicillin family drugs. That was a library addition using Crisper.... rather than a genetic mutation. Your username comes from that process. It's still an E-coli with a bigger library and a genetic variation. This ability is given to most lifeforms. Let me know when it turns into something that is not an E-coli. Does the citrate ability come via the Rogues' Gallery or from elsewhere in the genome? If the latter, what will happen if you took the citrate away for 75000 generations? Might it lose its ability to handle citrate? This reminds me of the moths in England that turned from a light shade to a dark shade and back to light again when the air pollution was cleaned up. I know you will attribute that to preditors. You actually need to do the other half of the experiment and put the new bug in an old environment for 75000 generations and see what it gains and loses.

    • Null Pointer
      Null Pointer

      lots of small changes eventually make large changes...

    • Crispr CAS9
      Crispr CAS9

      "No we're not viewing evolution as it happens." Evolution is the change in allele frequencies in a population over successive generations, which this definitely is. "It's still the same bug." It isn't the same, the descendant can use citrate as a sole carbon source, which the ancestor could not. They have identified the mutations responsible, which were not present in the ancestor. It is demonstrably different. "It hasn't turned into another kind of bacteria. " 'Kind' is a nonsense word without any scientific validity. "Major evolution would result in a different bacterium" Then mission accomplished, as explained above. "or a different plant." If any of the descendants of bacteria were plants, that would disprove evolution. Asking as evidence for a thing something that would actually disprove that thing is a fairly clear indication you don't understand the subject in the first place.

  • Oogie Padoogie
    Oogie Padoogie

    And in 30 more years (equivalent to 3 million years from the start), still nothing cool happened. Yawn.

  • Fred Leonard
    Fred Leonard

    Time for flask beer pong?

  • patricio patricio
    patricio patricio

    when you touch the elbow for said hi don't keep social distance needed for prevent covid

  • Adnan haider
    Adnan haider

    New Hollywood movie plot, Planet of the Bacteria.

    • Polaris Raven
      Polaris Raven

      So, as opposed to a Grey Goo scenario (Out of control Nano-Bot Replicators), this would be a Green Goo scenario?

  • random black hole
    random black hole

    So "life finds a way" even if it doesn't need to?

  • Jorjon Jorjon
    Jorjon Jorjon

    Imagine if we are just an experiment inside an alien race flask, and we die because otherwise the experiment would become unmanageable.

  • LoBoToM81
    LoBoToM81

    That was interesting.

  • Scott Pike
    Scott Pike

    33 years and it’s still bacteria.

    • Random Dude
      Random Dude

      Just as evolution predicts.

  • avadhut patil
    avadhut patil

    Everyone gangsta until bacteria evolve to have collective consciousness

  • tarkaras
    tarkaras

    i just love the hippie labcoat at 11.50 :-) ....sadly not gonna happen in my lab :-(

    • miko foin
      miko foin

      millennia of “hominid” evolution? So how long did it take to get to “hominid” again? Would you mind taking me through that process, even theoretically, step by step? I’m very

  • Mohammad Hasanain
    Mohammad Hasanain

    Tell me when the bacteria becomes a fish🤫

    • Crispr CAS9
      Crispr CAS9

      @Mohammad Hasanain "ok so you flipped to racism" Excuse me? That's a substantial accusation. Either support it or retract it. " I am a native speaker" Then the educational system has failed you. "and you judge me by my name" I judged you by your obvious inability to communicate in English. I had given you the benefit of the doubt that you were able to at least communicate in some other language. If you claim you're just incoherent generally, I'll take your word for it. When you've learned how words work and what a reasonable number of them mean, feel free to revisit this conversation and try again.

    • Mohammad Hasanain
      Mohammad Hasanain

      @Crispr CAS9 ok so you flipped to racism what would you do if I was in your county just god knows. All the things you talked about are things I can feel their influence but I can't feel the influence of the precious evolution. write what ever you want now, I will not answer you because I am a native speaker and you judge me by my name "science guy"

    • Crispr CAS9
      Crispr CAS9

      @Mohammad Hasanain "it's clear that you don't understand what am I saying" Given the fact that I am a native speaker of the language we're using, and I'm guessing you are not, I'd say that it is *much* more likely the problem is that *you* don't understand what I am saying. "so just answer this question, when was there any proof and I mean proof on evolution" Same time as there was proof of gravity: Never. There is no proof in science. If you deny evolution because there is no 'proof' then you must also deny gravity, electricity, the existence of microbes, and the reality of your own mind. Because you can't 'prove' any of them.

    • Mohammad Hasanain
      Mohammad Hasanain

      @Crispr CAS9 it's clear that you don't understand what am I saying or don't want to so just answer this question, when was there any proof and I mean proof on evolution and something transforming to something else like an ape or fish caroling out of the see 🤷🏽‍♂️

    • Crispr CAS9
      Crispr CAS9

      @Mohammad Hasanain "so science doesn't work on proof is that correct?" Yes. "If it is you're talking about a new science you invented" No. "and if you said "observed " an observation is enough proof for such a thing" An observation isn't proof. It is a data point that increases confidence. "where was it observed can you tell me?" PMC3277146 & PMC4380822, and others. "What I meant when I talked about the experiment was that it didn't happen in this experiment while it was this long, when can it happen?" Here's your logic, spot the error: "I just flipped a coin 5 times and didn't roll a six, therefore rolling a six with a fair die is impossible!" "So if I told you that I'm confident the moon is made of cheese" I'd be curious as to what statistical analysis you based that on, but strongly suspect you just didn't understand what I mean by 'confidence'. I'm using a statistical definition, not a common one.

  • Psychentist
    Psychentist

    Love the turbulent flow Tshirt. LOL. This little feud is hilarious and I'm here for it.

  • Larry Panozzo
    Larry Panozzo

    Generation 69,000: E. Coli have spelled out the words, “Let us out.”

  • kolim jone
    kolim jone

    I would love to sit in the lectures of this professor. It is so pleasant to hear him explain!

  • isaiah
    isaiah

    Lol, evolution isn’t real. There settled

    • Null Pointer
      Null Pointer

      lol, nobody of any relevance cares about your opinion.

  • avitarmageddon
    avitarmageddon

    Let's hope those bacterium are not harmful to life around them when they escape. I'm not qualified to know whether they represent a danger or not but I do know that no containment protocols are 100% guaranteed, never can be.

    • Heinrich Himla
      Heinrich Himla

      i feel as if they wont survive well in the wild considering they're evolving in extremely favourable conditions for them

  • Texas Ray
    Texas Ray

    What kind of idiots want to breed bacteria that are immune to antibiotics?

  • Eren JAEGER
    Eren JAEGER

    I wonder if it’s possible for a mutation to arise where it produces an antibiotic that it is immune to but the other members of the population aren’t. It would probably require a long chain of silent mutations to occur in a very specific way and the resistance ability would have to evolve shortly before the antibiotic ability otherwise it may be too prevalent in the population

  • Classic Riki
    Classic Riki

    This is extremely interesting, brilliant video all around. Something very disturbing about watching these bacteria evolve rapidly and seeing the rate explained compared to earth 🌍 while having seen them wearing masks due to Covid

  • Micro Scale
    Micro Scale

    Can anyone please explain why he used fluorescent powder and uv torch? Please please please🙏🙏🙏🙏🙄

  • Dylan Birrer
    Dylan Birrer

    absolute champ, this video is exactly what I need for the biology assessment I'm doing, there's so much useful information and you made me think about what I'm writing in a different light as well.

  • Strange Velocity
    Strange Velocity

    0:59 Before I watch this video again.. Where can I get that t shirt? :O

  • pNsB
    pNsB

    People saying “but they’re still bacteria” really have no clue how evolution works XD

    • Crispr CAS9
      Crispr CAS9

      @Hassan Selim "where no longer bacteria (eg: they became multicellular?)" Becoming multicellular wouldn't make them no longer bacteria. In fact, there *are* multicellular bacteria. Bacteria is a clade, and you can't escape your ancestry. Your descendants must always be in the same clades you are in, under evolutionary theory.

    • Hassan Selim
      Hassan Selim

      @Crispr CAS9 thank you for your great explanations, I just have a question about a statement you made. You said that if by the end of the experiment the resulting creatures where no longer bacteria (eg: they became multicellular?) then it would disprove evolution. Why is that?

    • Crispr CAS9
      Crispr CAS9

      @Stay Tune Kaison "no you cannot have one without the only" Organisms exist with one and not the other, so you are demonstrably wrong.

    • Stay Tune Kaison
      Stay Tune Kaison

      @Crispr CAS9 no you cannot have one without the only if you shoot someone an the heart stops the brain continues functioning for a while before it stops so it shows if u do have one without the other it won’t last very long And example would be a lizard an it’s take if you cut a lizards take it will still be moving for a little bit it will stop so it cannot work wit a much more complicated things such as the brain or the heart

    • Crispr CAS9
      Crispr CAS9

      @Stay Tune Kaison "Darwin and his discovery on the birds beaks was that evolution or adaptation" If we interpret the differences as adaptive, then it was adaptation. Regardless, it was absolutely evolution, since we've documented the changes in their genomes for the different populations. "and let’s move to Darwinian evolution" You want to 'move on' to something 150 years out of date? "so before humans existed the heart had to evolve and grow so did the brain" Apes have hearts. So do mammals. So do amniotes. So do vertebrates. So do chordates. But by the time you are back to basal chordates, you are talking about a 'heart' that is a single enlarged, centralized, and slightly more heavily muscled ventricle that is fully homologous with the distributed vesicles of other deuterostomes. Which are, in turn, homologous with the types of vesicles found in protostomes. Which is basically just a slightly increased musculature around a vessel to improve lymph circulation, which isn't even needed for the smallest organisms. And that is to say it is, in comparison to a human heart, *much* less than half a heart. And yet it worked just fine for those organisms in their environment. So you can actually trace the development of hearts all the way back to a point where they weren't even needed. You can do the same for brains. " so which came first cause you can’t have one without the other? " You absolutely can have one without the other. "When the first bacteria appeared it had to eat but the senses weren’t a thing so how did it know where to eat or eyes weren’t thing so how did it find it’s food again with no senses" The same way bacteria find food now, since they don't have eyes now either.

  • David Ghetto
    David Ghetto

    No gloves lol

  • gregormann7
    gregormann7

    The brainwashing on this subject is surpassed by no other! Absolutely astonishing. So 75,000 generations of bacteria becoming. . . um, bacteria. . . is the equivalent of 1500 millennia of “hominid” evolution? So how long did it take to get to “hominid” again? Would you mind taking me through that process, even theoretically, step by step? I’m very interested to know just how the suite of organs that fill the torso evolved into a coordinated interacting interdependent group of unique components comprising complex animal life. Like bacteria. . .becoming bacteria. And please, no assumed “populations” for a starting point.

    • Crispr CAS9
      Crispr CAS9

      "And please, no assumed “populations” for a starting point." Explain evolution, but don't talk about evolution? Sounds like you don't know what the subject is in the first place.

  • Adriana Gabriela
    Adriana Gabriela

    Well, this looks like a disaster waiting to happen (one day)

  • Abhin Aravind
    Abhin Aravind

    Yet people say Darwin is wrong and God is real 😂😂

    • srak 123
      srak 123

      Darwin doesn't have to be false for g-d to exist

  • Dan K
    Dan K

    So then one of these bacteria gets loose and infects the human population and low and behold there is no antibiotic that can save us. Did we not learn anything from the covid lab leak in wuhan???

  • Shipwright
    Shipwright

    Congrats! Sounds like a billion dollar experiment to prove how different breeds of dogs are possible. 😆

  • Rahul Raj
    Rahul Raj

    Religion has left the chat

  • Reyhan Alhafizal
    Reyhan Alhafizal

    I thought this video was about artificial neural network. Dammit.

  • LDPC
    LDPC

    Read a great book about this (and other experiments like it) on a flight the other day, Improbable Destinies by Jonathan Losos. In case anyone wants to go even more in depth!

  • ShadowdragonBAD
    ShadowdragonBAD

    Mirco evolution and natural selection/Adaptation is a cool thing.

  • Lorica Lass
    Lorica Lass

    You have been told over and over that change is Evolution. It is not. You are different from your parents and grandparents. But you are all still 100% Homo sapiens. Likewise, bacteria change. But they stay 100% bacteria in their bacterial domain. Bacteria have been observed since 1670, pretty much around the clock and around the world. Ancient fossilized bacteria have been found. They all have been nothing but bacteria. Change is not evolution. That is just one of the ridiculous mantras and myths used to support a pseudoscience narrative. You are not an ape or bacteria update. Find out who you really are. Look outside the box. The truth is there.

    • Preetha O.C
      Preetha O.C

      @Lorica Lass What I said is the definition of evolution, so by definition the bacteria did evolve. Evolution doesn't say a bacteria will become a non bacteria, it literally says the opposite. WHY IS IT SO HARD FOR YOU TO UNDERSTAND THAT? A species can become a different species, but it can't change its domain, kingdom, class, genus, etc.

    • Lorica Lass
      Lorica Lass

      @Preetha O.C You think that bacteria steadfastly staying nothing but bacteria is somehow showing Evolution. Do you think if you toss out the words allele frequency that just explains everything? It explains zero to support your case. The bacteria are still bacteria in their bacterial domain. They haven’t changed into a non-bacteria. They are no way evolving. There is zero evidence that any bacteria at any time has ever become a non-bacteria. There’s a lot of data about bacteria though! It’s all over the world presently and recorded from history. What does the real data show? Anything about allele frequencies to support Evolution? No it just shows bacteria staying bacteria. Every single time.Bacteria stay bacteria. Try to grasp that. Bacteria that stay bacteria aint evolving. This is a really simple concept. Try to wrap your head around it. If you can’t understand that then you have no right to be calling someone else stupid. Goodbye!

    • Preetha O.C
      Preetha O.C

      @Lorica Lass Kent Hovind doesn't understand evolution (or he is a con man that lies for a living, which is most likely the case). He has been corrected multiple times and still repeats the same stupidity.

    • Preetha O.C
      Preetha O.C

      @Lorica Lass I literally explained that evolution doesn't say a bacteria will become a non bacteria, it will become a different species of bacteria. Every descendant of every organism will be a part of every clade it's ancestor was part of EVEN IF it creates a new clade. One SPECIES can become a different species, but no other clade can change. Evolution is the change in allele frequencies of a population with generations, so even if it doesn't become a new species, it can still be considered evolution.

    • Lorica Lass
      Lorica Lass

      @Preetha O.C I’m sorry but your post doesn’t make any sense to me. You have been trying to deal in the imaginary, and the never seen, to defend your faith in evolution. You’re speculating about something that has never been seen, while ignoring all the great history of what has been seen. No such thing as a bacteria turning into a non-bacteria has ever happened. But we do know for sure that if a bacteria stays bacteria in its bacterial domain,it ain’t showing any evolution! It is showing the exact opposite of evolution. Therefore this whole video is based on a fantasy. You are believing a fantasy. Wake up. You are being had. Learn to think. Learn to do critical thinking. This is all so obvious. I should not have to repeat the obvious. I gave a reference of a video above which points out the absurdities of evolution over and over. Based on observable scientific data. If you don’t see the obvious, and you don’t want to look outside the box, then nothing further that I have to say to you will compute with you. Therefore, nothing personal, but to keep from wasting your precious time and mine you are now on mute. I pray that you will learn to see through scam artists like Richard Dawkins who tell you that you came from a bacteria, while ignoring the fact that, as I said already, all the evidence, even from ancient fossils, show that bacteria stay bacteria. Period. Yes, they changed somewhat. But they stay bacteria.

  • Misha Kos
    Misha Kos

    great watch

  • evangelizarEC
    evangelizarEC

    Here is a key question, how long will it take for this E. coli to turn into Salmonella? Or into Bacillus or Listeria?

    • Crispr CAS9
      Crispr CAS9

      @evangelizarEC "shows the equivalent hominid evolution" From Homo erectus to Homo sapiens. So still Homo. Of course, that happened in a population with a smaller effective population size and higher mutation rate in a highly variable and changing environment, all of which increases the rate you might expect differences to accumulate. "you still have E. coli but with one lineage able to consume citrate" Whether or not it is still E coli depends on how one delimits species. By 3% 16S, it would still be E coli, by ecotype delimitation, it would be a new species. But it would never be any currently extant species, because that's not how evolution works.

    • evangelizarEC
      evangelizarEC

      @Crispr CAS9 And I'm sure you'll be able to explain it to me so would like to hear it from you. What I'm pointing out is what is implied from the video (~2:20 shows the equivalent hominid evolution... at the end ~11 min, you still have E. coli but with one lineage able to consume citrate) - the changes observed are adaptations to the environment (~min 6-7). That's the discrepancy, according to the timeline portrayed, while hominids change... E. Coli stays E. Coli but now 1/12 of it can consume citrate. I'm anticipating that in another 3 decades... one will still find E. Coli.

    • Crispr CAS9
      Crispr CAS9

      If that's how you think evolution works, you don't understand how evolution works.